PUBLICATIONS (2008-present; From CSULB) graduate students underlined; undergraduates in bold
The research in Vas lab is currently funded by the National Institutes of Health (NIH).
Over the last 10 years, we acknowledge funding from the:
NIH
American Heart Association
Tobacco-Related Diseases Research Program
California State University
California State University Program for Education & Research in Biotechnology (CSUPERB)
CSUPERB-Howell Foundation
And from training programs such as AHA fellowships, the NIH T34 U-RISE, MARC, RISE and BUILD and the NSF LSAMP programs, CSUPERB and CSUPERB-Howell Program
- Galvez, G., Killilea, D. W., Berry, S., Narayanaswami, V. and Fung, E. (2024) Increasing STEM skills, knowledge and interest among diverse students: Results from an intensive summer research program at the University of California, San Francisco. Innovative Higher Education (In press).
- Benedicto, V., Haguar, Z., Abdulhasan, A. and Narayanaswami, V. (2024) Apolipoprotein E3 Containing Nanodiscs as Vehicles for Transport and Targeted Delivery of Flavonoid Luteolin. ACS Omega 9, 2988-2999. (doi: 10.1021/acsomega.3c09120) PMCID: PMC10795050
- Allen, P., Benedicto, V. G. L., Smith, A., Abdulhassan, A., Narayanaswami, V. and Tapavicza, E.* (2023) Molecular Dynamics Simulation of Apolipoprotein E3 Lipid Nanodiscs. Biochim. Biophys. Acta 1866, 184230
- Abeer, M §., Abdulhasan, A. §, Haguar, Z. and Narayanaswami, V. (2023) Isoform-specific Modification of Apolipoprotein E by 4-Hydroxynonenal: Protective Role of Apolipoprotein E3 Against Oxidative Species. FEBS J https://doi.org/10.1111/febs.16729 §Equal contribution
- Horn, J. V.C., Kakutani, L. M., Narayanaswami, V.* and Weers, P. M. M.* (2022) Insights into C-terminal Domain of Apolipoprotein E from Chimera Studies with Apolipophorin-III. Molecular and Cellular Biochemistry https://doi.org/10.1007/s11010-022-04497-y
- Kothari, S., Bala, N., Patel, A., Donovan, A. & Narayanaswami, V. (2021) The LDL Receptor Binding Domain of Apolipoprotein E Directs the Relative Orientation of its C-terminal Segment in Reconstituted Nascent HDL. Biochimica Biophysica Acta (Biomembranes) (In Press)
- Chuang, S. T., Cruz, S. & Narayanaswami, V. (2020) Review: Reconfiguring nature’s cholesterol accepting lipoproteins as nanoparticle platforms for transport and delivery of therapeutic and imaging agents. Nanomaterials: Protein Nanostructures for Biomedical Applications, 10, 906 (doi:10.3390/nano10050906) (PMCID: PMC7279153)
- Cruz, S. & Narayanaswami, V. (2019) Cellular Uptake and Clearance of Oxidatively-modified Apolipoprotein E3 by Cerebral Cortex Endothelial Cells. International Journal of Molecular Sciences, 20, 4582 (PMCID: PMC6769588)
- Suematsu, Y., Park, C., Ane Nunes, A., Jing, W.-H., Melissa Soohoo, M., Streja, E., Rhee, C., Cruz, S., Kashyap, M. L., Vaziri, N. D., Naranayaswami, V., Kalantar-Zadeh, K., & Moradi, H. (2019) Association of Serum Paraoxonase/Arylesterase Activity with All-Cause Mortality in Maintenance Hemodialysis Patients. Journal of Clinical Endocrinology & Metabolism, 104, 4848-4856 (PMCID: PMC6733492)
- Tu, K.-H., Abhari, D. and Narayanaswami, V. (2019) Conformational Analysis of Apolipoprotein (apo) E3apoE4 heteromerization. FEBS J. 286, 1986-1998 (PMCID: PMC6733585)
- Yang, Y., Hernandez, R. V., Tran, T. T., Nirudodhi, S., Beck, W. H., Maier, C. S. & Narayanaswami, V. (2018) Ordered Opening of LDL Receptor binding domain of Human Apolipoprotein E3 Revealed by Hydrogen/Deuterium Exchange Mass Spectrometry and Fluorescence Spectroscopy. Biochim. Biophys. Acta – Proteins & Proteomics, 1866, 1165-1173 (PMID: 30282614).
- Chuang, S. T., Shon, Y.-S., & Narayanaswami, V. (2017) Apolipoprotein E3 Mediated Targeted Delivery of 3, 10 and 17 nm Gold Nanoparticles Embedded in Reconstituted High Density Lipoprotein. Internatl. J. Nanomed. 12, 8495-8510 (PMCID# PMC5708192)
- Lek, M. T., Cruz, S., Ibe, N. U., Beck, W. H. J., Bielicki, J. K., Weers, P. M. M. & Narayanaswami, V. (2017) Swapping the N- and C-terminal Domains of Apolipoprotein E3 and AI Reveals New Insights into their Structure/Activity Relationship. PLOS One 12, e0178346 (PMCID # PMC5482431)
- Horn, J. V. C., Ellena, R. A., Tran, J. J., Beck, W. H. J., Narayanaswami, V. Weers, P. M. M. (2017) Transfer of C-terminal residues of human apolipoprotein A-I to insect apolipophorin III creates a two-domain chimeric protein with enhanced lipid binding activity. Biochim. Biophys. Acta (Biomembranes) 1859, 1317-1325 (PMCID # PMC5518692)
- Safina, D., Romeo, R., Schlitt, F., Pflanzner, T., Claus U. Pietrzik, C. U., Narayanaswami, V., Edenhofer, F. & Faissner, A. (2016) Low-density Lipoprotein Receptor-related Protein 1 (LRP1) is a Novel Modulator of Radial Glia Stem Cell Proliferation, Survival and Differentiation. Glia 64, 1363-1380 (PMCID# PMC5033964) (Cover image: http://onlinelibrary.wiley.com/doi/10.1002/glia.v64.8/issuetoc)
- Fabilane, C. S., Nguyen, P. N., Hernandez, R. V., Nirudodhi , S., Duong, M., Maier, C. S. and Narayanaswami, V. (2016) Mechanism of Lipid Binding of Human Apolipoprotein E3 by Hydrogen/Deuterium Exchange/Mass Spectrometry and Fluorescence Polarization. Protein & Peptide Lett. 23, 404-413 (PMID # 26902251; PMCID in process)
- Kim, S. H., Cruz, S., Adhikari, B. B., Schramm, M. P., Vinson, J. A. & Narayanaswami, V. (2015) Targeted Intracellular Delivery of Resveratrol to Glioblastoma Cells using Apolipoprotein E-Containing Reconstituted HDL as a Nanovehicle. PLoS ONE 10, e0135130 (PMCID # PMC4530947)
- Kim, S. H., Kothari, S., Patel, A. B., Bielicki, J. K. & Narayanaswami, V. (2014) A Pyrene Based Fluorescence Approach to Study Conformation of Apolipoprotein E3 in Macrophage-generated Nascent High Density Lipoprotein. Biochem. Biophys. Res. Commun. 450, 124-128 (PMCID # PMC4130211)
- Tran, T. N., Kosaraju, M. G., Tamamizu-Kato, S., Akintunde, O., Zheng, Y., Bielicki, J. K., Pinkerton, K, Uchida, K., Lee, Y. Y. & Narayanaswami, V. (2014) Acrolein Modification Impairs Key Functional Features of Rat Apolipoprotein E: Identification of Modified Sites by Mass Spectrometry. Biochemistry 53, 361-375 (PMCID # PMC3937454).
- Zheng, Y., Patel, A. B., Narayanaswami, V. & Bielicki, J. K. (2013) Retention of α-helical structure by HDL mimetic peptide ATI-5261 upon extensive dilution represents an important determinant for stimulating ABCA1 cholesterol efflux with high efficiency. Biochem. Biophys. Res. Commun. 441, 71-76 (PMID # 24129191).
- Tran, T. N., Kim, S. H., Gallo, C., Amaya, M., Kyees, J. and Narayanaswami, V. (2013) Biochemical and Biophysical Characterization of Recombinant Rat Apolipoprotein E: Similarities to Human Apolipoprotein E3. Arch. Biochem. Biophys. 259, 18-25 (PMCID # PMC3543869)
- Zheng, Y., Kim, S. H., Patel, A. B., Narayanaswami, V, Iavarone, A. T., Hura, G. L. & Bielicki, J. K. (2012) The positional specificity of EXXK motifs within an amphipathic α-helix dictates preferential lysine modification by acrolein: Implications for the design of high-density lipoprotein mimetic peptides. Biochemistry 51, 6400-6412 (PMCID # 22800301)
- Bains, G. K., Kim, S. H., Sorin, E. J. & Narayanaswami, V. (2012) Extent of pyrene fluorescence emission is a reflector of distance and flexibility: Analysis of the segment linking the LDL receptor-binding and tetramerization domains of apolipoprotein E3. Biochemistry 51, 6207-6219 (PMCID # PMC3448802)
- Bains, G., Patel, A. B. and Narayanaswami, V. (2011) Pyrene: A probe to study protein conformation and conformational changes. Molecules 16, 7909-7935
- Zheng, Y.*, Patel A. B.*, Narayanaswami, V., Hura, G. L., Hang, B., and Bielicki, J. K. (2011) HDL mimetic peptide ATI-5261 forms an oligomeric assembly in solution that dissociates to monomers upon dilution. Biochemistry 50, 4068-4076 (*equal contribution)
- Khumsupan, P., Ramirez, R., Khumsupan, D. and Narayanaswami, V. (2011) Apolipoprotein E LDL receptor-binding domain-containing high-density lipoprotein: A nanovehicle to transport curcumin, an antioxidant and anti-amyloid bioflavonoid. Biochim Biophys Acta 1808, 352-359 (PMCID: PMC2997894)
- Hauser, P. S., Narayanaswami, V. and Ryan, R. O. (2011) Review: Apolipoprotein E: From lipid transport to neurobiology. Prog. Lipid Res. 50, 62-74
- Bielicki, J. K., Zhang, H., Cortez, Y., Narayanaswami, V., Patel, A. B., Johansson, J. and Azhar, S. (2010) A new HDL mimetic peptide that stimulates cellular cholesterol efflux with high efficiency greatly reduces atherosclerosis in mice. J. Lipid Res. 51, 1496-1503
- Patel, A. B., Khumsupan, P. and Narayanaswami, V. (2010) Pyrene Fluorescence Analysis Offers New Insights into the Conformation of the Lipoprotein-Binding Domain of Human Apolipoprotein E. Biochemistry 49, 1766-1775
- Crutcher, K. A., Lilley, H. N., Anthony, S. R., Zhou, W. and Narayanaswami, V. (2010) Full-length apolipoprotein E protects against the neurotoxicity of an apoE-related peptide. Brain Research 1306, 106-115
- Narayanaswami, V., Kiss, R. S. and Weers, P. M. (2010) Review: The helix bundle: a reversible lipid binding motif. Comparative Biochem. Physiol. A Mol. Integr. Physiol. 155, 123-133 (PMCID: PMC2808439)
- Cerf, E., Sarroukh, R., Tamamizu-Kato, S., Derclaye, S., Dufrêne, Y., Narayanaswami, V., Goormaghtigh, E., Ruysschaert, J.-M. and Raussens, V. (2009) Anti-parallel b-sheet - A signature structure of the oligomeric amyloid-beta peptide. Biochemical J. 421, 415-423 (PMID: 19435461)
- Posse de Chaves, E. and Narayanaswami, V. (2008) Review: Apolipoprotein E and Cholesterol Transport in Aging and Disease. Invited review article Future Lipidology 3, 505-530 (PMCID: PMC2600507)
The research in Vas lab is currently funded by the National Institutes of Health (NIH).
Over the last 10 years, we acknowledge funding from the:
NIH
American Heart Association
Tobacco-Related Diseases Research Program
California State University
California State University Program for Education & Research in Biotechnology (CSUPERB)
CSUPERB-Howell Foundation
And from training programs such as AHA fellowships, the NIH T34 U-RISE, MARC, RISE and BUILD and the NSF LSAMP programs, CSUPERB and CSUPERB-Howell Program